[Determination of interleukin-6 messenger RNA as malignant progression index in monoclonal gammapathy of undetermined significance].

The monoclonal gammopathy of undetermined significance (MGUS) could be considered a preneoplastic condition since no clinical and laboratory features are able to identify in advance the patients at high risk of disease progression. In this study we analysed IL-6mRNA expression on both bone marrow mononuclear cells and peripheral blood mononuclear cells sample of multiple myeloma (MM) and MGUS patients for evaluation if IL-6mRNA expression could be considered diagnostic or prognostic aspect of progression disease risk to MM. We concluded that expression of IL-6mRNA hasn't prognostic significance for the progression disease risk to multiple myeloma but could have a discriminant significance the MM and MGUS pathologies when combined with gene rearrangements and immunochemicals analysis.