Current medical science · 2021
Glucose Metabolic Alteration of Cerebral Cortical Subareas in Rats with Renal Ischemia/Reperfusion Based on Small-Animal Positron Emission Tomography.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chen Ming, Zhang Mei, Li Zhi-Xiao, Xiang Hong-Bing, Xiong Jun
Аннотация
OBJECTIVE: To investigate glucose metabolic alterations in cerebral cortical subareas using 18F-labeled glucose derivative fluorodeoxyglucose (FDG) micro-positron emission tomography (PET) scanning in a rat renal ischemia/reperfusion (RIR) model.
METHODS: Small-animal PET imaging in vivo was performed with 18F-labeled FDG as a PET tracer to identify glucose metabolic alterations in cerebral cortical subregions using a rat model of RIR.
RESULTS: We found that the average standardized uptake value (SUVaverage) of the cerebral cortical subareas in the RIR group was significantly increased compared to the sham group (P<0.05). We also found that glucose uptake in different cortical subregions including the left auditory cortex, right medial prefrontal cortex, right para cortex, left retrosplenial cortex, right retrosplenial cortex, and right visual cortex was significantly increased in the RIR group (P<0.05), but there was no significant difference in the SUVaverage of right auditory cortex, left medial prefrontal cortex, left para cortex, and left visual cortex between the two groups.
CONCLUSION: The 18F-FDG PET data suggests that RIR causes a profound shift in the metabolic machinery of cerebral cortex subregions.
METHODS: Small-animal PET imaging in vivo was performed with 18F-labeled FDG as a PET tracer to identify glucose metabolic alterations in cerebral cortical subregions using a rat model of RIR.
RESULTS: We found that the average standardized uptake value (SUVaverage) of the cerebral cortical subareas in the RIR group was significantly increased compared to the sham group (P<0.05). We also found that glucose uptake in different cortical subregions including the left auditory cortex, right medial prefrontal cortex, right para cortex, left retrosplenial cortex, right retrosplenial cortex, and right visual cortex was significantly increased in the RIR group (P<0.05), but there was no significant difference in the SUVaverage of right auditory cortex, left medial prefrontal cortex, left para cortex, and left visual cortex between the two groups.
CONCLUSION: The 18F-FDG PET data suggests that RIR causes a profound shift in the metabolic machinery of cerebral cortex subregions.