Pathology, research and practice · 2015
Increasing demonstration of angiogenic markers in skin neoplastic lesions.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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de Almeida Carla Mendonça, de Jesus Sabina Ferreira, Poswar Fabiano de Oliveira, Gomes Emisael Stênio Batista, Fraga Carlos Alberto de Carvalho, Farias Lucyana Conceição, Santos Sérgio Henrique Souza, Feltenberger John David, de Paula Alfredo Maurício Batista, Guimarães André Luiz Sena
Аннотация
BACKGROUND: Skin cancer represents the most common worldwide malignancy. Angiogenesis is an important factor in tumor growth and metastasis. Given these facts, the purpose of the current study was to compare the levels of angiogenic proteins in the context of the most common malignant and premalignant skin lesions.
METHODS: Immunohistochemistry of CD31, HIF1A, VEGFR1 and VEGFR2 was performed in basal cell carcinoma (BCC), actinic keratosis (AK) and squamous cell carcinoma of the skin (SCCS).
RESULTS: SCCS presented with increased levels of HIF1A, VEGFR1 and VEGFR2 in comparison to AK. In addition, SCCS also demonstrated increased levels of HIF1A to BCCLR or BCCHR. BCC presented with more vessels than AK. However, no correlation was observed among CD31, HIF1A, VEGFR1 and VEGFR2.
CONCLUSIONS: SCCS presented with higher levels of HIF1A, VEGFR1 and VEGFR2, while BCC demonstrated an increased number of vessels in relation to AK. These data suggest that antiangiogenic therapy might be useful for skin cancer treatment.
METHODS: Immunohistochemistry of CD31, HIF1A, VEGFR1 and VEGFR2 was performed in basal cell carcinoma (BCC), actinic keratosis (AK) and squamous cell carcinoma of the skin (SCCS).
RESULTS: SCCS presented with increased levels of HIF1A, VEGFR1 and VEGFR2 in comparison to AK. In addition, SCCS also demonstrated increased levels of HIF1A to BCCLR or BCCHR. BCC presented with more vessels than AK. However, no correlation was observed among CD31, HIF1A, VEGFR1 and VEGFR2.
CONCLUSIONS: SCCS presented with higher levels of HIF1A, VEGFR1 and VEGFR2, while BCC demonstrated an increased number of vessels in relation to AK. These data suggest that antiangiogenic therapy might be useful for skin cancer treatment.
Предметные рубрики MeSH
Angiogenic ProteinsBasal Cell CarcinomaCarcinoma, Squamous CellHumansHypoxia-Inducible Factor 1, alpha SubunitImmunohistochemistryKeratosis, ActinicNeovascularization, PathologicPlatelet Endothelial Cell Adhesion Molecule-1Retrospective StudiesSkin NeoplasmsVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth Factor Receptor-2