Journal of experimental & clinical cancer research : CR · 2015
The efficacy of a photolyase-based device on the cancerization field: a clinical and thermographic study.
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Laino Luigi, Elia Fulvia, Desiderio Flora, Scarabello Alessandra, Sperduti Isabella, Cota Carlo, DiCarlo Aldo
Аннотация
BACKGROUND: At skin level, a cancerization field (CF) indicates some chronically photoexposed areas in which, besides a primary tumor, histological or biomolecular modifications without clinical signs are present. Active telethermography (ATT) allows us to observe the imaging of a hyperthermic halo (HH) surrounding the tumor . The Authors hypothesize HH as a possible expression of CF.
OBJECTIVES: The aim of this study were to verify whether HHs have the same histological or immunohistochemical characteristics as the CF and, secondly, to evaluate the efficacy of a device containing the enzyme photolyase in modifying thermographic parameters in these area.
METHODS: The study included 30 patients affected by actinic keratosis, evaluated clinically and by ATT at time 0 and after 3, 6 and 9 months.
RESULTS: The ATT showed the presence of HHs in all the patients and, after the treatment, a significant modification of both the extension of these areas and the thermal parameters. In 5 patients for whom, while operated, two other biopsies were performed, respectively on the HH and on a perilesional non-hyperthermic area, in the HH, we detected a p53 and Ki 67 over-expression.
CONCLUSIONS: Our results indicate that ATT could represent a useful paraclinic method in identifying CFs in subjects at risk.
OBJECTIVES: The aim of this study were to verify whether HHs have the same histological or immunohistochemical characteristics as the CF and, secondly, to evaluate the efficacy of a device containing the enzyme photolyase in modifying thermographic parameters in these area.
METHODS: The study included 30 patients affected by actinic keratosis, evaluated clinically and by ATT at time 0 and after 3, 6 and 9 months.
RESULTS: The ATT showed the presence of HHs in all the patients and, after the treatment, a significant modification of both the extension of these areas and the thermal parameters. In 5 patients for whom, while operated, two other biopsies were performed, respectively on the HH and on a perilesional non-hyperthermic area, in the HH, we detected a p53 and Ki 67 over-expression.
CONCLUSIONS: Our results indicate that ATT could represent a useful paraclinic method in identifying CFs in subjects at risk.