Indian journal of psychiatry · 2024
Within-session habituation and salivary cortisol during exposure treatment in obsessive-compulsive disorder - A link and an influence of DHEA?
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kellner Michael, Yassouridis Alexander, Muhtz Christoph, Wiedemann Klaus
Аннотация
BACKGROUND: Glucocorticoids increase fear extinction in preclinical and human studies. Endogenous cortisol might influence who will benefit from exposure therapy in anxiety-spectrum disorders.
METHODS: To investigate the impact of cortisol levels on within-session habituation of distress - a measure of success of exposure therapy - in obsessive-compulsive disorder (OCD) fifty-one OCD patients were studied during their stressful first cognitive-behavioral exposure therapy session with response prevention. Subjective units of distress, salivary cortisol, and salivary dehydroepiandrosterone (DHEA) were measured repeatedly before and during this afternoon session.
RESULTS: No significant association of within-session habituation of distress and cortisol level during exposure was found. Calculating with the cortisol/DHEA ratio, similar results emerged.
CONCLUSION: Studies using endogenous diurnal fluctuation of cortisol and studies with administration of exogenous cortisol are needed to test whether glucocorticoids can augment exposure session outcome.
METHODS: To investigate the impact of cortisol levels on within-session habituation of distress - a measure of success of exposure therapy - in obsessive-compulsive disorder (OCD) fifty-one OCD patients were studied during their stressful first cognitive-behavioral exposure therapy session with response prevention. Subjective units of distress, salivary cortisol, and salivary dehydroepiandrosterone (DHEA) were measured repeatedly before and during this afternoon session.
RESULTS: No significant association of within-session habituation of distress and cortisol level during exposure was found. Calculating with the cortisol/DHEA ratio, similar results emerged.
CONCLUSION: Studies using endogenous diurnal fluctuation of cortisol and studies with administration of exogenous cortisol are needed to test whether glucocorticoids can augment exposure session outcome.