Seborrhea and persistent tardive dyskinesia.

The following communication concerns two schizophrenic patients with Tardive dyskinesia (TD) in whom fluctuations in the severity of the dyskinesias were accompanied by changes in the severity of the seborrheic skin lesions. Since seborrheic dermatitis may be associated with increased plasma melanocyte-stimulating hormone (MSH) level, these observations suggest an association between the severity of TD and increased pituitary MSH release. In addition, TD may be associated with hypothalamic-pituitary dysfunction of MSH autoregulation.