Case reports in oncology · 2025
Long-Term Effectiveness and Safety of Isatuximab in Combination with Pomalidomide and Dexamethasone in a Japanese Patient with Refractory Multiple Myeloma and 1q21 Amplification: A Case Report.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Yoshioka Takanori, Sando Yasuhisa, Sunami Kazutaka
Аннотация
INTRODUCTION: In the ICARIA-MM trial, isatuximab plus pomalidomide-dexamethasone (Pd) significantly prolonged progression-free survival, compared with Pd alone, in patients with relapsed or refractory multiple myeloma (RRMM), including those with gain or amplification of chromosome 1q, region 2, band 1 (1q21+).
CASE PRESENTATION: We describe a 62-year-old Japanese man with 1q21+ RRMM, previously treated with three lines of therapy, who had a rapid and durable response to isatuximab-Pd. After the first isatuximab-Pd cycle, he had a complete response or better, which was maintained throughout 54 cycles (4.25 years). Isatuximab-Pd was generally well tolerated. The only serious adverse event was grade 3 cataracts.
CONCLUSION: Our case shows that isatuximab-Pd is capable of inducing an enduring response in a patient with 1q21+ RRMM.
CASE PRESENTATION: We describe a 62-year-old Japanese man with 1q21+ RRMM, previously treated with three lines of therapy, who had a rapid and durable response to isatuximab-Pd. After the first isatuximab-Pd cycle, he had a complete response or better, which was maintained throughout 54 cycles (4.25 years). Isatuximab-Pd was generally well tolerated. The only serious adverse event was grade 3 cataracts.
CONCLUSION: Our case shows that isatuximab-Pd is capable of inducing an enduring response in a patient with 1q21+ RRMM.