Corneal scarring following collagen cross-linking: evidence of increased lysyl oxidase activity.

PURPOSE: To report a case of corneal scarring following collagen cross linking in a young female.

METHODS

A 24-year-old female presented to us with complaints of decreased vision and a white spot in her left eye following collagen cross linking (CXL) performed elsewhere, four years prior. We diagnosed her as a case of left eye leucomatous corneal opacity for which she underwent optical penetrating keratoplasty under local anaesthesia. The excised corneal tissue was evaluated by routine histopathology and immunohistochemistry.

RESULTS

At the final follow up visit, one year following corneal transplantation, her visual acuity improved to 20/20, J1 with a clear graft.

CONCLUSION

Vision threatening corneal scarring may be rarely noted following CXL.