Leukemia research · 2024
Outcomes of hematopoietic stem cell transplantation in primary plasma cell leukemia: A systematic review and meta-analysis.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shahzad Moazzam, Iqbal Qamar, Amin Muhammad Kashif, Irfan Sohaib, Warraich Sarmad Zaman, Anwar Iqra, Dave Prashil, Basharat Ahmad, Hebishy Ahmed, Faisal Muhammad Salman, Jaglal Michael, Mushtaq Muhammad Umair
Аннотация
BACKGROUND: Hematopoietic stem cell transplantation (HCT) is a pivotal treatment modality for primary plasma cell leukemia (pPCL). We aimed to examine the outcomes of allogeneic (allo) and autologous (auto) HCT in adult pPCL patients.
METHODS: Following PRISMA guidelines, a comprehensive literature search was performed on PubMed, Cochrane, Embase, and Clinicaltrials.gov using relevant MeSH terms and keywords. Twelve original articles reporting outcomes of auto-HCT or allo-HCT in adult pPCL patients were included. The pooled analysis was performed using the 'meta' package in the R program (version 4.3.0).
RESULTS: Our analysis included 1757 pPCL patients (1535 with auto-HCT, 222 with allo-HCT), and 49 % were males. The pooled 3 years overall survival (OS), progression-free survival/event-free survival (PFS/EFS), and relapse rate (RR) in auto-HCT were 51 % (95 % CI 0.4-0.61, I2=92 %, p = <0.01), 36 % (95 % CI 0.24-0.52, I 2 =97 %, p < 0.01), and 68 % (95 % CI, 0.65-0.71, I2=0 %, p = 0.42), respectively. Among allo-HCT recipients, the reported OS varied from 71 % at 2.3 years to 31 % at 4 years and EFS/PFS from 29 % at 2.5 years to 19 % at 4 years. The pooled treatment-related mortality (TRM) was 12 % (95 % CI 0.05-0.25, I 2=35 %, p = 0.22) at a median of 6 months. The pooled incidence of acute and chronic graft versus host disease was 27 % (0.19-0.36, I2= 30 %, p = 0.21) and 36 % (0.27-0.45, I2= 24 %, p = 0.26), respectively.
CONCLUSION: HCT remains pivotal in treating primary plasma cell leukemia. However, higher relapse rates warrant novel agents and clinical trials to improve transplant-related outcomes in this challenging subgroup.
METHODS: Following PRISMA guidelines, a comprehensive literature search was performed on PubMed, Cochrane, Embase, and Clinicaltrials.gov using relevant MeSH terms and keywords. Twelve original articles reporting outcomes of auto-HCT or allo-HCT in adult pPCL patients were included. The pooled analysis was performed using the 'meta' package in the R program (version 4.3.0).
RESULTS: Our analysis included 1757 pPCL patients (1535 with auto-HCT, 222 with allo-HCT), and 49 % were males. The pooled 3 years overall survival (OS), progression-free survival/event-free survival (PFS/EFS), and relapse rate (RR) in auto-HCT were 51 % (95 % CI 0.4-0.61, I2=92 %, p = <0.01), 36 % (95 % CI 0.24-0.52, I 2 =97 %, p < 0.01), and 68 % (95 % CI, 0.65-0.71, I2=0 %, p = 0.42), respectively. Among allo-HCT recipients, the reported OS varied from 71 % at 2.3 years to 31 % at 4 years and EFS/PFS from 29 % at 2.5 years to 19 % at 4 years. The pooled treatment-related mortality (TRM) was 12 % (95 % CI 0.05-0.25, I 2=35 %, p = 0.22) at a median of 6 months. The pooled incidence of acute and chronic graft versus host disease was 27 % (0.19-0.36, I2= 30 %, p = 0.21) and 36 % (0.27-0.45, I2= 24 %, p = 0.26), respectively.
CONCLUSION: HCT remains pivotal in treating primary plasma cell leukemia. However, higher relapse rates warrant novel agents and clinical trials to improve transplant-related outcomes in this challenging subgroup.