Diagnostics (Basel, Switzerland) · 2024
Flower-Shaped Plasma Cells in Multiple Myeloma with Morphological Heterogeneity.
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Hosoi Hiroki, Tane Misato, Sogabe Makiko, Iwamoto Ryuta, Minoura Naoto, Murata Shogo, Mushino Toshiki, Nishikawa Akinori, Murata Shin-Ichi, Sonoki Takashi
Аннотация
BACKGROUND: Flower-shaped nuclei in plasma cells are rare in multiple myeloma.
CASE PRESENTATION: We report on an 88-year-old male who presented with a mass lesion in the clavicular region. A biopsy of the mass revealed an increase in mature plasma cells with round nuclei. In contrast, a bone marrow examination showed increased plasma cells with flower-shaped nuclei. The patient tested negative for human T-lymphotropic virus type-1 and was diagnosed with multiple myeloma.
CONCLUSIONS: While multiple myeloma is known for intra-tumor heterogeneity, reports of morphological heterogeneity based on the site of tumor sampling are limited. In this case, the presence of plasma cells with flower-shaped nuclei enabled the identification of site-dependent morphological tumor heterogeneity.
CASE PRESENTATION: We report on an 88-year-old male who presented with a mass lesion in the clavicular region. A biopsy of the mass revealed an increase in mature plasma cells with round nuclei. In contrast, a bone marrow examination showed increased plasma cells with flower-shaped nuclei. The patient tested negative for human T-lymphotropic virus type-1 and was diagnosed with multiple myeloma.
CONCLUSIONS: While multiple myeloma is known for intra-tumor heterogeneity, reports of morphological heterogeneity based on the site of tumor sampling are limited. In this case, the presence of plasma cells with flower-shaped nuclei enabled the identification of site-dependent morphological tumor heterogeneity.