Journal of clinical anesthesia · 2016
Magnesium sulfate accelerates the onset of low-dose rocuronium in patients undergoing laryngeal microsurgery.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Choi Eun-Su, Jeong Woo-Jin, Ahn Soon-Hyun, Oh Ah-Young, Jeon Young-Tae, Do Sang-Hwan
Аннотация
STUDY OBJECTIVE: We evaluated the effect of magnesium sulfate-an enhancer of neuromuscular blockade-on onset and duration of low dose of rocuronium, and on operating conditions during laryngeal microsurgery.
DESIGN: Randomized, prospective, double-blinded study.
PATIENTS: Eighty-four patients scheduled for elective laryngeal microsurgery.
INTERVENTIONS: Patients were randomly allocated to receive different doses of rocuronium: 0.6 mg/kg (group C, n=28), 0.45 mg/kg (group LR, n=28), or 0.45 mg/kg plus magnesium sulfate 30 mg/kg (group LM, n=28).
MEASUREMENTS: We measured the onset time and duration of action of rocuronium, and evaluated the surgeon's satisfaction with the operating conditions.
MAIN RESULTS: Group LR showed significantly delayed onset time (group C: 87±22 seconds, group LR: 127±47 seconds, and group LM: 89±32 seconds; P=.001) and maximal suppression than did other groups (group C: 102±30 seconds, group LR: 155±66 seconds, and group LM: 105±36 seconds; P=.002). Duration of action of rocuronium was significantly longer in group C than in other groups (group C: 39±7 minutes, group LR: 28±8 minutes, group LRM: 31±8 minutes; P<.001). Laryngoscope placement score (P=.002), surgeon's satisfaction (P=.005), and sore throat (P=.035) were significantly worse in group LR.
CONCLUSIONS: Magnesium sulfate 30 mg/kg accelerated the onset and improved operating conditions of low-dose rocuronium without prolongation of action.
DESIGN: Randomized, prospective, double-blinded study.
PATIENTS: Eighty-four patients scheduled for elective laryngeal microsurgery.
INTERVENTIONS: Patients were randomly allocated to receive different doses of rocuronium: 0.6 mg/kg (group C, n=28), 0.45 mg/kg (group LR, n=28), or 0.45 mg/kg plus magnesium sulfate 30 mg/kg (group LM, n=28).
MEASUREMENTS: We measured the onset time and duration of action of rocuronium, and evaluated the surgeon's satisfaction with the operating conditions.
MAIN RESULTS: Group LR showed significantly delayed onset time (group C: 87±22 seconds, group LR: 127±47 seconds, and group LM: 89±32 seconds; P=.001) and maximal suppression than did other groups (group C: 102±30 seconds, group LR: 155±66 seconds, and group LM: 105±36 seconds; P=.002). Duration of action of rocuronium was significantly longer in group C than in other groups (group C: 39±7 minutes, group LR: 28±8 minutes, group LRM: 31±8 minutes; P<.001). Laryngoscope placement score (P=.002), surgeon's satisfaction (P=.005), and sore throat (P=.035) were significantly worse in group LR.
CONCLUSIONS: Magnesium sulfate 30 mg/kg accelerated the onset and improved operating conditions of low-dose rocuronium without prolongation of action.
Предметные рубрики MeSH
AdultAgedAndrostanolsDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug SynergismHumansIntubation, IntratrachealLaryngoscopyLarynxMagnesium SulfateMicrosurgeryMiddle AgedNeuromuscular BlockadeNeuromuscular JunctionNeuromuscular Nondepolarizing AgentsPharyngitisRocuroniumYoung Adult