Cancers · 2024
First-Line Use of Daratumumab in Patients with Multiple Myeloma Shows Delayed Neutrophil and Platelet Engraftment after Autologous Stem Cell Transplantation: Results from a Real-Life Single-Center Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Martino Massimo, Gori Mercedes, Porto Gaetana, Policastro Giorgia, Pitea Martina, Sgarlata Annalisa, Delfino Ilaria Maria, Cogliandro Francesca, Scopelliti Anna, Utano Giovanna, Pellicano Maria, Idato Aurora, Vincelli Iolanda Donatella, Marafioti Violetta, Micò Maria Caterina, Lazzaro Giuseppe, Loteta Barbara, Alati Caterina, Leanza Giovanni, D'Arrigo Graziella, Tripepi Giovanni Luigi, Pitino Annalisa
Аннотация
BACKGROUND: This real-life study aimed to investigate the possible impact of D-VTd induction therapy on hematopoietic engraftment after autologous stem cell transplantation (auto-SCT).
METHODS: Sixty consecutive NDMM patients received four cycles of induction therapy with D-VTd. The conditioning regimen consisted of melphalan 200 mg/m2. These patients were compared with a historical control group of 80 patients who received four cycles of VTd as induction therapy.
RESULTS: The median days to reach neutrophil and platelet engraftment significantly differed between patients treated with D-VTd (11 and 13 days, respectively) and VTd (10 and 12 days). Univariate Cox analyses show that patients treated with D-VTd had a hazard ratio of neutrophil engraftment that was 42% significantly lower than those in the VTd arm (HR: 0.58, p = 0.002), and a multivariate model confirmed this result. Patients treated with D-VTd developed FN more frequently. Univariate and multivariate logistic regressions revealed an association between D-VTd and FN. Delayed engraftment did not correlate with more extended hospitalization. No patients died in the first six months after transplantation.
CONCLUSIONS: Our real-life study showed that a four-drug induction therapy containing DARA does not impact transplant safety outcomes.
METHODS: Sixty consecutive NDMM patients received four cycles of induction therapy with D-VTd. The conditioning regimen consisted of melphalan 200 mg/m2. These patients were compared with a historical control group of 80 patients who received four cycles of VTd as induction therapy.
RESULTS: The median days to reach neutrophil and platelet engraftment significantly differed between patients treated with D-VTd (11 and 13 days, respectively) and VTd (10 and 12 days). Univariate Cox analyses show that patients treated with D-VTd had a hazard ratio of neutrophil engraftment that was 42% significantly lower than those in the VTd arm (HR: 0.58, p = 0.002), and a multivariate model confirmed this result. Patients treated with D-VTd developed FN more frequently. Univariate and multivariate logistic regressions revealed an association between D-VTd and FN. Delayed engraftment did not correlate with more extended hospitalization. No patients died in the first six months after transplantation.
CONCLUSIONS: Our real-life study showed that a four-drug induction therapy containing DARA does not impact transplant safety outcomes.