Acute pancreatitis related to hypercalcemia as initial manifestation of cancer: About 4 cases.

Acute pancreatitis is a frequent gastrointestinal emergency seen in tertiary care hospitals. While gallstones and chronic alcohol consumption remain the most common causes, other etiologies can also be identified, notably hypercalcemia, which constitutes a rare yet deadly cause of acute pancreatitis. Herein, we report 4 cases of AP related to hypercalcemia from malignancies: 2 cases of multiple myeloma, one case of rectal malignancy, and 1 case of medullary thyroid carcinoma associated with a parathyroid adenoma. Among these cases, one patient died, one developed exocrine and endocrine pancreatic insufficiency, and another progressed to end-stage chronic renal failure. Awareness of hypercalcemia of malignancy as an exceptional etiology of AP is crucial for timely diagnosis and appropriate management of these cases.