An evolutionary machine learning for multiple myeloma using Runge Kutta Optimizer from multi characteristic indexes.

Multiple myeloma (MM) is a malignant plasma cell disease that is the second most prevalent hematological malignancy in high-income nations and accounts for around 1.8% of all cancers and 18% of hematologic malignancies in the United States. In this research, we try to design a machine learning framework for MM diagnosis from multi characteristic indexes using slime mould Runge Kutta Optimizer (MSRUN) and kernel extreme learning machine, which is called as MSRUN-KELM. An efficient slime mould learning operator is introduced to the initial Runge Kutta Optimizer in MSRUN, ensuring that the trade-off between intensity and diversity is satisfied. The MSRUN was evaluated using IEEE CEC2014 benchmark functions, and the statistical results indicate a significant increase in the search performance of MSRUN. In MSRUN-KELM, kernel extreme machine learning is constructed on MM from multi-characteristic indexes with MSRUN, parameter optimization, and feature selection synchronized by MSRUN. The results of MSRUN-KELM on MM are accuracy of 93.88%, a Matthews correlation coefficient of 0.922677, and sensitivities of 93.41% and 93.19%. The suggested MSRUN-KELM may be utilized to analyze MM from multi-characteristic indexes well, and it can be treated as a potential tool for MM diagnosis.