Future oncology (London, England) · 2023
In-class transition from bortezomib-based therapy to IRd is an effective approach in newly diagnosed multiple myeloma.
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Rifkin Robert M, Costello Caitlin L, Birhiray Ruemu E, Kambhampati Suman, Richter Joshua, Abonour Rafat, Lee Hans C, Stokes Michael, Ren Kaili, Stull Dawn Marie, Cherepanov Dasha, Bogard Kimberly, Noga Stephen J, Girnius Saulius
Аннотация
Aim: To compare the effectiveness of in-class transition to all-oral ixazomib-lenalidomide-dexamethasone (IRd) following parenteral bortezomib (V)-based induction versus continued V-based therapy in US oncology clinics. Patients & methods: Non-transplant eligible patients with newly diagnosed multiple myeloma (MM) receiving in-class transition to IRd (N = 100; US MM-6), or V-based therapy (N = 111; INSIGHT MM). Results: Following inverse probability of treatment weighting, overall response rate was 73.2% with IRd versus 57.5% with V-based therapy (p < 0.0001). Median duration of treatment was 10.8 versus 5.3 months (p < 0.0001). Overall, 18/24% of patients discontinued IRd/V-based therapy due to adverse events. Conclusion: IRd after V-based induction was associated with significantly improved overall response rate and duration of treatment than continued V-based combination therapy. Clinical Trial Registration: US MM-6: NCT03173092; INSIGHT MM: NCT02761187 (ClinicalTrials.gov).