Environmental research · 2023
Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts.
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Hvidtfeldt Ulla Arthur, Chen Jie, Rodopoulou Sophia, Strak Maciej, de Hoogh Kees, Andersen Zorana J, Bellander Tom, Brandt Jørgen, Forastiere Francesco, Brynedal Boel, Hertel Ole, Hoffmann Barbara, Katsouyanni Klea, Ketzel Matthias, Leander Karin, Magnusson Patrik K E, Nagel Gabriele, Pershagen Göran, Rizzuto Debora, Samoli Evangelia, So Rina, Stafoggia Massimo, Tjønneland Anne, Weinmayr Gudrun, Wolf Kathrin, Zitt Emanuel, Brunekreef Bert, Hoek Gerard, Raaschou-Nielsen Ole
Аннотация
BACKGROUND: Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated.
METHODS: We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.
RESULTS: During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10-5 m-1 BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3.
CONCLUSIONS: We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.
METHODS: We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.
RESULTS: During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10-5 m-1 BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3.
CONCLUSIONS: We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.