Vox sanguinis · 1998
Evaluation of the microcolumn technology for pretransfusion testing in multiple myeloma patients.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fabijańska-Mitek J, Zupańska B, Pogłód R, Gorajek M, Lopieńska H, Kraj M
Аннотация
OBJECTIVE: Microcolumn tests are useful for serological investigations, although because of their high sensitivity, false-positive results might be expected, e.g. in hypergammaglobulinemia. The aim of this study was to evaluate these tests in multiple myeloma.
METHODS: Pretransfusion testing was done in 80 patients with multiple myeloma using microcolumn and traditional tube tests.
RESULTS: All sera were negative in microcolumn indirect antiglobulin test and enzyme test, positive in 58% of samples in the enzyme tube test. The microcolumn direct antiglobulin test was positive in about 40% of samples but never in the tube direct antiglobulin test. This was not due to the presence of autoantibodies but to nonspecific binding of immunoglobulins related to their concentration in sera.
CONCLUSION: Microcolumn tests appeared to be useful for pretransfusion testing in multiple myeloma in spite of positive autocontrols.
METHODS: Pretransfusion testing was done in 80 patients with multiple myeloma using microcolumn and traditional tube tests.
RESULTS: All sera were negative in microcolumn indirect antiglobulin test and enzyme test, positive in 58% of samples in the enzyme tube test. The microcolumn direct antiglobulin test was positive in about 40% of samples but never in the tube direct antiglobulin test. This was not due to the presence of autoantibodies but to nonspecific binding of immunoglobulins related to their concentration in sera.
CONCLUSION: Microcolumn tests appeared to be useful for pretransfusion testing in multiple myeloma in spite of positive autocontrols.
Предметные рубрики MeSH
AdultAgedAged, 80 and overBlood Grouping and CrossmatchingCoombs TestEvaluation Studies as TopicFalse Positive ReactionsFemaleGelsHumansImmunoenzyme TechniquesImmunoglobulin GImmunoglobulin MImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsImmunologic TechniquesImmunophenotypingMaleMiddle AgedMultiple Myeloma