Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
The Therapeutic Effect of High-definition 1-Hz Transcranial Alternating Current Stimulation in PTSD: A Randomized Controlled Trial.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hatef Boshra, Jahromi Gila Pirzad, Khaleghi Ali, Radfar Shokofeh
Аннотация
OBJECTIVE: Post-traumatic stress disorder (PTSD) is a serious mental health challenge that usually lacks effective responses to conventional therapies. High-definition transcranial alternating current stimulation (HD-tACS) is gaining attention as a potential therapeutic approach for neuropsychiatric disorders. This study aimed to investigate the effects of 1-Hz tACS on PTSD symptoms.
METHODS: A randomized controlled trial involving 40 PTSD patients was designed. Patients were randomly divided into sham and real stimulation groups and underwent 10 HD-tACS sessions. We used 1-Hz HD-tACS with the central anode positioned at T8 and the ring cathodes at P8, C4, F8 and EX10 (targeting right lateral temporal cortex). Clinical symptoms of patients were evaluated through the PTSD Checklist for DSM-5 (PCL-5). Also, we measured salivary cortisol levels and serum brain-derived neurotrophic factor (BDNF) levels before and after treatment.
RESULTS: The real stimulation resulted in a more significant reduction in PTSD symptoms as measured by the mean PCL-5 score (56.25 ± 12.13 to 39.40 ± 13.91) compared to the sham stimulation (p < 0.05). The mean salivary cortisol level increased significantly in the real stimulation group (0.053 ± 0.04 μg/dl to 0.10 ± 0.07 μg/dl) compared to the sham (p < 0.001). In contrast, serum BDNF levels showed no significant changes in either group.
CONCLUSION: Preliminary findings suggest that HD-tACS in delta band can significantly alleviate PTSD symptoms, indicating its potential as a therapeutic intervention for PTSD.
METHODS: A randomized controlled trial involving 40 PTSD patients was designed. Patients were randomly divided into sham and real stimulation groups and underwent 10 HD-tACS sessions. We used 1-Hz HD-tACS with the central anode positioned at T8 and the ring cathodes at P8, C4, F8 and EX10 (targeting right lateral temporal cortex). Clinical symptoms of patients were evaluated through the PTSD Checklist for DSM-5 (PCL-5). Also, we measured salivary cortisol levels and serum brain-derived neurotrophic factor (BDNF) levels before and after treatment.
RESULTS: The real stimulation resulted in a more significant reduction in PTSD symptoms as measured by the mean PCL-5 score (56.25 ± 12.13 to 39.40 ± 13.91) compared to the sham stimulation (p < 0.05). The mean salivary cortisol level increased significantly in the real stimulation group (0.053 ± 0.04 μg/dl to 0.10 ± 0.07 μg/dl) compared to the sham (p < 0.001). In contrast, serum BDNF levels showed no significant changes in either group.
CONCLUSION: Preliminary findings suggest that HD-tACS in delta band can significantly alleviate PTSD symptoms, indicating its potential as a therapeutic intervention for PTSD.