Post-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ghamgosar Shahkhali Morvarid, Liu Lang, Ghamgosar Shahkhali Mohammad H, Yu Eric, Asayesh Farnaz, Ahmad Jamil, Teferra Meron, Arnulf Isabelle, Dodet Pauline, Ju Yo-El, Hu Michele T M, Montplaisir Jacques Y, Gagnon Jean-François, Desautels Alex, Ibrahim Abubaker, Stefani Ambra, Högl Birgit, Akrtan-Süzgün Merve, Iranzo Alex, Serradell Mónica, Montini Angelica, Maya Gerard, Gaig Carles, Luigi Gigli Gian, Valente Mariarosaria, Janes Francesco, Bernardini Andrea, Dauvilliers Yves, Sonka Karel, Kemlink David, Dusek Petr, Sommerauer Michael, Tamgüney Gültekin, Figorilli Michela, Puligheddu Monica, Cochen De Cock Valerie, Oertel Wolfgang, Janzen Annette, Antelmi Elena, Mollenhauer Brit, Trenkwalder Claudia, Sixel-Doring Friederike, Terzaghi Michele, Fiamingo Giuseppe, Skorvanek Matej, Kulcsarova Kristina, Abril Beatriz, Charley Monaca Christelle, Ferini-Strambi Luigi, Bušková Jitka, Orso Beatrice, Mattioli Pietro, Arnaldi Dario, Dijkstra Femke, Viaene Mineke, Boeve Bradley F, Ross Owen A, Rouleau Guy A, Neilson Lee E, Elliott Jonathan E, Lim Miranda M, Postuma Ronald B, Gan-Or Ziv
Аннотация
METHODS: We conducted polygenic risk score, genetic correlation, and Mendelian randomization analyses using the latest genome-wide association studies summary statistics and individual genotyping data. Next, a blinded observer examined dopamine transporter imaging binding status-a marker of neurodegeneration-in patients with isolated/idiopathic rapid-eye movement sleep behavior disorder, with (N = 6) and without Post-Traumatic Stress Disorder (N = 32).
RESULTS: Polygenic risk scores for Post-Traumatic Stress Disorder were associated with isolated/idiopathic rapid-eye-movement sleep behavior disorder, with each standard deviation increase linked to 14.7% higher odds (odds ratio = 1.15, 95% confidence interval: 1.04 to 1.26, p = 0.005). However, genetic correlation was weak, and Mendelian randomization did not support a potential causal relationship. The proportion of individuals with abnormal dopamine transporter imaging binding status was significantly higher in the Post-Traumatic Stress Disorder group compared to those without the disorder (p=0.01, X2 = 6.62).
INTERPRETATION: Polygenic risk scores analysis identified an association between Post-Traumatic Stress Disorder and neurodegeneration-related isolated/idiopathic rapid-eye-movement sleep behavior disorder, consistent with the result from the small exploratory substudy. The lack of strong genetic correlation or causation may reflect limited sample size. Further research with larger and more diverse cohorts is crucial to clarify the genetic, biological and physiological mechanisms underlying this association.