British journal of obstetrics and gynaecology · 1993
Abnormal fetal immunological development in Down's syndrome.
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Thilaganathan B, Tsakonas D, Nicolaides K
Аннотация
OBJECTIVE: To investigate the intrauterine development of the immune system in Down's syndrome.
DESIGN: Cross sectional study.
SETTING: Harris Birthright Research Centre for Fetal Medicine, London, UK.
SUBJECTS: 16 fetuses with Down's syndrome and 104 fetuses with a normal karyotype at 17-24 weeks gestation.
MAIN OUTCOME MEASURE: Flow cytometry was used to enumerate T (CD3+), B (CD19+) and NK (CD3- & CD16+/CD56+) lymphocyte subpopulations in fetal blood obtained by cordocentesis.
RESULTS: The median numbers of T, B and NK lymphocytes in fetuses with Down's syndrome (1.52 x 10(9)/l, 0.08 x 10(9)/l, and 0.10 x 10(9)/l, respectively) were significantly lower than in the chromosomally normal fetuses (T lymphocytes: 1.98 x 10(9)/l, z = 3.04, P < 0.01; B lymphocytes: 0.50 x 10(9)/l, z = 5.84, P < 0.0001; and NK lymphocytes: 0.19 x 10(9)/l, z = 3.14, P < 0.01).
CONCLUSION: These data demonstrate that in Down's syndrome, there is abnormal intra-uterine development of the immune system.
DESIGN: Cross sectional study.
SETTING: Harris Birthright Research Centre for Fetal Medicine, London, UK.
SUBJECTS: 16 fetuses with Down's syndrome and 104 fetuses with a normal karyotype at 17-24 weeks gestation.
MAIN OUTCOME MEASURE: Flow cytometry was used to enumerate T (CD3+), B (CD19+) and NK (CD3- & CD16+/CD56+) lymphocyte subpopulations in fetal blood obtained by cordocentesis.
RESULTS: The median numbers of T, B and NK lymphocytes in fetuses with Down's syndrome (1.52 x 10(9)/l, 0.08 x 10(9)/l, and 0.10 x 10(9)/l, respectively) were significantly lower than in the chromosomally normal fetuses (T lymphocytes: 1.98 x 10(9)/l, z = 3.04, P < 0.01; B lymphocytes: 0.50 x 10(9)/l, z = 5.84, P < 0.0001; and NK lymphocytes: 0.19 x 10(9)/l, z = 3.14, P < 0.01).
CONCLUSION: These data demonstrate that in Down's syndrome, there is abnormal intra-uterine development of the immune system.