Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery · 2008
[Effect of METH1 gene transfection on the proliferation of rabbit's ear scar].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Song Bao-Qiang, Lu Kai-Hua, Guo Shu-Zhong, Zhang Yang, Peng Pai, Ma Fu-Cheng, Li Hui-Yuan
Аннотация
OBJECTIVE: To investigate the effect of METH1 gene transfection on fibroblast proliferation and I, III collagen synthesis in rabbit ear scar.
METHODS: The hypertrophic scar model on the rabbit ears was reproduced. 10 days after epithelization, Ad-METH1 was injected into the scar tissue. 30 days later, the effect of METH1 gene transfection on the angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue was detected by microcirculation microscope, AgNOR particle count and collagen dyeing.
RESULTS: 30 days after injection of Ad-METH1, angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue were obviously suppressed.
CONCLUSION: Early application of Ad-METH1 after epithelization can markedly inhibit the formation of the hypertrophic scar.
METHODS: The hypertrophic scar model on the rabbit ears was reproduced. 10 days after epithelization, Ad-METH1 was injected into the scar tissue. 30 days later, the effect of METH1 gene transfection on the angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue was detected by microcirculation microscope, AgNOR particle count and collagen dyeing.
RESULTS: 30 days after injection of Ad-METH1, angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue were obviously suppressed.
CONCLUSION: Early application of Ad-METH1 after epithelization can markedly inhibit the formation of the hypertrophic scar.