Медицинская библиотека · Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery · 2008

[Effect of METH1 gene transfection on the proliferation of rabbit's ear scar].

Song Bao-Qiang, Lu Kai-Hua, Guo Shu-Zhong, Zhang Yang, Peng Pai, Ma Fu-Cheng, Li Hui-Yuan

Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

To investigate the effect of METH1 gene transfection on fibroblast proliferation and I, III collagen synthesis in rabbit ear scar.

METHODS

The hypertrophic scar model on the rabbit ears was reproduced. 10 days after epithelization, Ad-METH1 was injected into the scar tissue. 30 days later, the effect of METH1 gene transfection on the angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue was detected by microcirculation microscope, AgNOR particle count and collagen dyeing.

RESULTS

30 days after injection of Ad-METH1, angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue were obviously suppressed.

CONCLUSION

Early application of Ad-METH1 after epithelization can markedly inhibit the formation of the hypertrophic scar.

Для цитирования: Song Bao-Qiang, Lu Kai-Hua, Guo Shu-Zhong, Zhang Yang, Peng Pai, Ma Fu-Cheng, Li Hui-Yuan. [Effect of METH1 gene transfection on the proliferation of rabbit's ear scar].. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. 2008.

Предметные рубрики MeSH

ADAM Proteins Angiogenesis Inhibitors Animals Cicatrix, Hypertrophic Disease Models, Animal Ear Ear, External Female Male Microcirculation Neovascularization, Pathologic Rabbits Transfection Wound Healing

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