Granulomatous lesions of unknown significance in biopsies from lymph-nodes and other tissues: the GLUS-syndrome.

Granulomatous lesions of unknown significance (GLUS) have been described primarily in liver and lymph-node biopsies, and the overall frequency of GLUS among all types of granulomatous lesions is approximately 20-25%. Regardless of localization GLUS is characterized by a benign self-healing course. The combination of this clinical picture with a characteristic histomorphologic and immunohistologic pattern appears to justify the proposal of the existence of a special GLUS-syndrome, possibly with a single or a few related etiologies.