Cyclosporin A in nontransplant-related liver disease.

Cyclosporin A is a potent immunosuppressive agent that has revolutionized the care of organ transplant recipients. Recently, the use of cyclosporin A has been extended beyond the transplant setting to include certain disorders that are thought to be immunologically mediated. This review focuses on the results of cyclosporin A in the treatment of nontransplant-related liver disorders including primary biliary cirrhosis, autoimmune chronic active (lupoid) hepatitis, primary sclerosing cholangitis, schistosomiasis, acute fulminant hepatitis, and chronic granulomatous liver disease.