PLoS neglected tropical diseases · 2020
High-quality nuclear genome for Sarcoptes scabiei-A critical resource for a neglected parasite.
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Korhonen Pasi K, Gasser Robin B, Ma Guangxu, Wang Tao, Stroehlein Andreas J, Young Neil D, Ang Ching-Seng, Fernando Deepani D, Lu Hieng C, Taylor Sara, Reynolds Simone L, Mofiz Ehtesham, Najaraj Shivashankar H, Gowda Harsha, Madugundu Anil, Renuse Santosh, Holt Deborah, Pandey Akhilesh, Papenfuss Anthony T, Fischer Katja
Аннотация
The parasitic mite Sarcoptes scabiei is an economically highly significant parasite of the skin of humans and animals worldwide. In humans, this mite causes a neglected tropical disease (NTD), called scabies. This disease results in major morbidity, disability, stigma and poverty globally and is often associated with secondary bacterial infections. Currently, anti-scabies treatments are not sufficiently effective, resistance to them is emerging and no vaccine is available. Here, we report the first high-quality genome and transcriptomic data for S. scabiei. The genome is 56.6 Mb in size, has a a repeat content of 10.6% and codes for 9,174 proteins. We explored key molecules involved in development, reproduction, host-parasite interactions, immunity and disease. The enhanced 'omic data sets for S. scabiei represent comprehensive and critical resources for genetic, functional genomic, metabolomic, phylogenetic, ecological and/or epidemiological investigations, and will underpin the design and development of new treatments, vaccines and/or diagnostic tests.