Antibacterial ent-trachyloban-19-oic acid and other constituents from Croton kinondoensis G.W. Hu, Ngumbau & Q.F. Wang.

Phytochemical analysis of the twigs and leaves of Croton kinondoensis, endemic to Kenya, yielded known compounds 3-(3',4'-dimethoxyphenyl)-prop-1-ene (1), 3-(3',4'-dimethoxyphenyl)-propenal (2), lupeol (3) and ent-trachyloban-19-oic acid (4), and a tentatively new ent-clerodane diterpenoid, crotokinondoenolide (5). ent-Trachy-loban-19-oic acid (4) showed good activity against a panel of drug-resistant strains of Staphylococcus aureus and Enterococcus spp with MIC -values of 25 µg/mL.