Approximating dementia prevalence in population-based surveys of aging worldwide: An unsupervised machine learning approach.

INTRODUCTION

Ability to determine dementia prevalence in low- and middle-income countries (LMIC) remains challenging because of frequent lack of data and large discrepancies in dementia case ascertainment.

METHODS

High likelihood of dementia was determined with hierarchical clustering after principal component analysis applied in 10 population surveys of aging: HRS (USA, 2014), SHARE (Europe and Israel, 2015), MHAS (Mexico, 2015), ELSI (Brazil, 2016), CHARLS (China, 2015), IFLS (Indonesia, 2014-2015), LASI (India, 2016), SAGE-Ghana (2007), SAGE-South Africa (2007), SAGE-Russia (2007-2010). We approximated dementia prevalence using weighting methods.

RESULTS

Estimated numbers of dementia cases were: China, 40.2 million; India, 18.0 million; Russia, 5.2 million; Europe and Israel, 5.0 million; United States, 4.4 million; Brazil, 2.2 million; Mexico, 1.6 million; Indonesia, 1.3 million; South Africa, 1.0 million; Ghana, 319,000.

DISCUSSION: Our estimations were similar to prior ones in high-income countries but much higher in LMIC. Extrapolating these results globally, we suggest that almost 130 million people worldwide were living with dementia in 2015.