Heart & lung : the journal of critical care · 2014
Heart rate variability parameters and ventricular arrhythmia correlate with pulmonary arterial pressure in adult patients with idiopathic pulmonary arterial hypertension.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Yi Hung-Tao, Hsieh Yu-Cheng, Wu Tsu-Juey, Huang Jin-Long, Lin Wei-Wen, Liang Kae-Woei, Su Chieh-Shou, Tsai Wan-Jane, Wang Kuo-Yang
Аннотация
OBJECTIVE: This aim of this study was to correlate heart rate variability (HRV) parameters to pulmonary arterial pressure (PAP) in patients with purely idiopathic pulmonary arterial hypertension (IPAH).
BACKGROUND: HRV is decreased in patients with PAH. Whether HRV indices can be used to assess PAP in IPAH patients remains unclear.
METHODS: HRV parameters obtained by 24-h ECG were evaluated in 26 IPAH patients and 51 controls.
RESULTS: Time-domain HRV parameters (SDNN, p < 0.0001; SDANN, p < 0.0001; RMSSD, p = 0.006) were lower in IPAH patients. Frequency-domain indices (high-frequency power, HFP, p = 0.001; low-frequency power, LFP, p = 0.003; total power, TP, p = 0.001) were also decreased in IPAH patients. In IPAH patients, RMSSD (p = 0.001), HFP (p = 0.015), and LFP (p = 0.027) were significantly correlated with PAP. IPAH patients had longer QTc intervals (p < 0.0001) and more premature ventricular contractions (p < 0.0001) than controls.
CONCLUSIONS: IPAH is associated with autonomic dysfunction. RMSSD, HFP, and LFP may be used as a supplemental tool to assess PAP in IPAH patients. IPAH patients with autonomic dysfunction are at high risk for ventricular arrhythmia.
BACKGROUND: HRV is decreased in patients with PAH. Whether HRV indices can be used to assess PAP in IPAH patients remains unclear.
METHODS: HRV parameters obtained by 24-h ECG were evaluated in 26 IPAH patients and 51 controls.
RESULTS: Time-domain HRV parameters (SDNN, p < 0.0001; SDANN, p < 0.0001; RMSSD, p = 0.006) were lower in IPAH patients. Frequency-domain indices (high-frequency power, HFP, p = 0.001; low-frequency power, LFP, p = 0.003; total power, TP, p = 0.001) were also decreased in IPAH patients. In IPAH patients, RMSSD (p = 0.001), HFP (p = 0.015), and LFP (p = 0.027) were significantly correlated with PAP. IPAH patients had longer QTc intervals (p < 0.0001) and more premature ventricular contractions (p < 0.0001) than controls.
CONCLUSIONS: IPAH is associated with autonomic dysfunction. RMSSD, HFP, and LFP may be used as a supplemental tool to assess PAP in IPAH patients. IPAH patients with autonomic dysfunction are at high risk for ventricular arrhythmia.