British journal of cancer · 2010
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden.
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Shu X, Ji J, Li X, Sundquist J, Sundquist K, Hemminki K
Аннотация
BACKGROUND: The possibility of an association of Graves' disease (GD) with subsequent cancers raised by certain studies.
METHODS: Using a database on 18 156 hospitalised GD patients, subsequent cancers were ascertained.
RESULTS: Increased risks of thyroid and parathyroid tumours were limited to the early follow-up period, which is probably a surveillance bias. Cancer sites with observed excess included the mouth and breast, in contrast to decreased risks of colon cancer, melanoma and non-Hodgkin's lymphoma.
CONCLUSION: Increased subsequent cancers in GD patients appeared to be balanced by decreased risks at other sites; chance cannot be excluded.
METHODS: Using a database on 18 156 hospitalised GD patients, subsequent cancers were ascertained.
RESULTS: Increased risks of thyroid and parathyroid tumours were limited to the early follow-up period, which is probably a surveillance bias. Cancer sites with observed excess included the mouth and breast, in contrast to decreased risks of colon cancer, melanoma and non-Hodgkin's lymphoma.
CONCLUSION: Increased subsequent cancers in GD patients appeared to be balanced by decreased risks at other sites; chance cannot be excluded.