Terapevticheskii arkhiv · 2008
[Morphofunctional characteristics of neutrophils in patients with autoimmune thyroiditis].
Аннотация на английскомСтатьяНазвание и аннотация: Оригинал на русском
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Rustembekova S A, Ametov A S, Vasilenko I A, Metelin V B
Аннотация
AIM: To study morphofunctional status of neutrophilic polymorphonuclear leukocytes (NPNL) in patients with chronic autoimmune thyroiditis (CAIT).
MATERIAL AND METHODS: The morphofunctional status of NPNL was investigated with vital computer phasic morphometry (CPM) in 25 patients (24 females and 1 male, mean age 45.4 +/- 3.2 years) with verified CAIT and 20 healthy females. Solid phase enzyme immunoassay examined the serum for IL-8 content.
RESULTS: CAIT patients have characteristic features of neutrophil morphofunctional state (changed cell size, disproportion in population morphological structure), IL-8 level was 13.9 fold higher than normal--63.8 pg/ml.
CONCLUSION: CAIT patients demonstrate activation of the mechanisms which regulate cell nonspecific resistence. As a result, locomotor, secretory and phagocytic NPNL functions enhance. Changes detected may reflect severity of the pathological process and indicate growing autoaggression in CAIT patients.
MATERIAL AND METHODS: The morphofunctional status of NPNL was investigated with vital computer phasic morphometry (CPM) in 25 patients (24 females and 1 male, mean age 45.4 +/- 3.2 years) with verified CAIT and 20 healthy females. Solid phase enzyme immunoassay examined the serum for IL-8 content.
RESULTS: CAIT patients have characteristic features of neutrophil morphofunctional state (changed cell size, disproportion in population morphological structure), IL-8 level was 13.9 fold higher than normal--63.8 pg/ml.
CONCLUSION: CAIT patients demonstrate activation of the mechanisms which regulate cell nonspecific resistence. As a result, locomotor, secretory and phagocytic NPNL functions enhance. Changes detected may reflect severity of the pathological process and indicate growing autoaggression in CAIT patients.