Fourth national Japanese antimicrobial susceptibility pattern surveillance program: Bacterial isolates from patients with complicated urinary tract infections.
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Kobayashi Kanao, Takahashi Satoshi, Yasuda Mitsuru, Miyazaki Jun, Wada Koichiro, Matsumoto Masahiro, Hayami Hiroshi, Yamamoto Shingo, Kiyota Hiroshi, Sato Junko, Matsumoto Tetsuya, Hasegawa Naoki, Kobayashi Intetsu, Masumori Naoya, Kimura Takahiro, Yamada Hiroki, Nakagawa Tohru, Kaneko Tomoyuki, Matsumoto Kazumasa, Fujimura Tetsuya, Kamei Jun, Ishikawa Kiyohito, Fujimoto Kiyohide, Nakai Yasushi, Shigemura Katsumi, Sadahira Takuya, Hinata Nobuyuki, Kitano Hiroyuki, Yamashita Masuo, Yasufuku Tomihiko, Komeda Hisao, Hiyama Yoshiki, Takahashi Yoshito, Kanamaru Sojun, Murakami Masaya, Arakawa Soichi, Yamada Daisuke, Mita Koji, Hamasuna Ryoichi, Tanaka Kazushi, Matsukawa Masanori, Takaoka Eiichiro, Shigeta Masanobu, Takenaka Tadasu, Nishino Masashi, Ishitoya Satoshi, Hayakawa Shohei, Okumura Kazuhiro, Ueda Masakatsu
Аннотация
MATERIALS AND METHODS: Data were collected for the fourth national surveillance project from July 2020 to December 2021 by the Japanese Society of Chemotherapy, the Japanese Association for Infectious Disease, and the Japanese Society of Clinical Microbiology. Surveillance was supervised with the cooperation of 43 medical institutions throughout Japan.
RESULTS: Fluoroquinolone required a minimum inhibitory concentration (MIC) of 2-64 mg/L to inhibit the 330 tested Escherichia coli strains. The proportion of levofloxacin-resistant E. coli strains increased from 28.6% in 2008 to 29.6% in 2011, 38.5% in 2015, and 44.5% in 2021. The proportion of levofloxacin-resistant strains of Pseudomonas aeruginosa also increased from previous survey results, showing a continuing downward trend. Conversely, the proportion of levofloxacin-resistant strains of Enterococcus faecalis decreased relative to previous reports. Neither multidrug-resistant P. aeruginosa nor carbapenem-resistant Enterobacteriaceae were detected. For methicillin-resistant Staphylococcus aureus (MRSA), the proportion of vancomycin-susceptible strains (MIC of 2 μg/mL) decreased from 14.7% to 7.7%.
DISCUSSION: Bacterial strains that produced extended-spectrum β-lactamase included E. coli (82/330 strains, 24.8%), Klebsiella pneumoniae (11/68 strains, 16.2%), and Proteus mirabilis (4/26 strains, 15.4%). As compared to previous surveillance reports, these strains showed an increase in proportion over the years.