Viruses · 2022
Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field.
БиографияИсторическая статьяСтатьяОбзорПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Bonavia Aurelio, Dominguez Samuel R, Dveksler Gabriela, Gagneten Sara, Howard Megan, Jeffers Scott, Qian Zhaohui, Smith Mary Kathryn, Thackray Larissa B, Tresnan Dina B, Wentworth David E, Wessner David R, Williams Richard K, Miura Tanya A
Аннотация
Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on coronaviruses developed over decades by researchers, including Kathryn (Kay) Holmes. Kay's research team discovered the first coronavirus receptors for mouse hepatitis virus and human coronavirus 229E and contributed a wealth of information on coronaviral spike glycoproteins and receptor interactions that are critical determinants of host and tissue specificity. She collaborated with several research laboratories to contribute knowledge in additional areas, including coronaviral pathogenesis, epidemiology, and evolution. Throughout her career, Kay was an extremely dedicated and thoughtful mentor to numerous graduate students and post-doctoral fellows. This article provides a review of her contributions to the coronavirus field and her exemplary mentoring.