Reassessing the role of amyloid in isolated REM sleep behavior disorder.

We investigated the causal relationship between cortical amyloid-β (Aβ) deposition, isolated REM sleep behavior disorder (iRBD), and Lewy body dementia (LBD) using Mendelian randomization (MR) analysis. Our findings revealed no causal link between Aβ deposition and iRBD/LBD, suggesting amyloid accumulation in iRBD is likely a coexisting phenomenon rather than a primary driver of disease progression.