HPA-axis abnormalities in psychiatrically well controls.

The considerable divergence in the literature describing dexamethasone suppression test (DST) nonsuppression rates among psychiatrically well controls led the authors to explore screening procedures as a possible source of variance. Using what they judged to be a typical screening procedure, the authors eliminated 69 of 128 subjects responding to an advertisement seeking psychiatrically and physically healthy subjects. Structured interviews for Axis I and II disorders then revealed that 36% of the remaining 59 subjects nevertheless had historical evidence of psychiatric illness; the 38 who passed all phases of screening underwent three monthly DSTs, which demonstrated the stability over time of both normal and abnormal results. Moreover, a family study revealed that relatives of nonsuppressors had a significantly higher morbid risk of affective disorder (20.5% vs. 8.8%), particularly mania and hypomania.