The American journal of gastroenterology · 2025
Different Survival Outcomes of Small Bowel Adenocarcinomas and T-Cell Lymphomas Associated With Celiac Disease.
СтатьяСравнительное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Santacroce Giovanni, Vanoli Alessandro, Aronico Nicola, Bianchi Paola Ilaria, Lenti Marco Vincenzo, Ciacci Carolina, Zingone Fabiana, Volta Umberto, Calabrò Antonio, Elli Luca, Ciccocioppo Rachele, Corazza Gino Roberto, Lucioni Marco, Paulli Marco, Di Sabatino Antonio, Small Bowel Cancer Consortium
Аннотация
INTRODUCTION: Small bowel adenocarcinoma (SBA) and T-cell lymphoma (TCL) are rare but aggressive malignancies associated with celiac disease (CD).
METHODS: We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.
RESULTS: CD-associated SBA showed a significantly ( P < 0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL but only in one SBA.
DISCUSSION: Our findings demonstrated a worse prognosis of CD-associated TCL in comparison with CD-associated SBA.
METHODS: We retrospectively compared 43 CD-associated SBA and 43 CD-associated TCL across international referral centers.
RESULTS: CD-associated SBA showed a significantly ( P < 0.01) better survival than CD-associated TCL. TCL more frequently presented with multifocal involvement and advanced stage, whereas SBA predominantly involved the jejunum. Refractoriness to a gluten-free diet was identified in 70% of TCL but only in one SBA.
DISCUSSION: Our findings demonstrated a worse prognosis of CD-associated TCL in comparison with CD-associated SBA.