Emerging infectious diseases · 2023
Clonal Dissemination of Antifungal-Resistant Candida haemulonii, China.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Chen Xinfei, Jia Xinmiao, Bing Jian, Zhang Han, Hong Nan, Liu Yun, Xi Haiyang, Wang Weiping, Liu Zhiyong, Zhang Qiangqiang, Li Li, Kang Mei, Xiao Yuling, Yang Bin, Lin Yulan, Xu Hui, Fan Xin, Huang Jingjing, Gong Jie, Xu Juan, Xie Xiuli, Yang Wenhang, Zhang Ge, Zhang Jingjia, Kang Wei, Wang He, Hou Xin, Xiao Meng, Xu Yingchun
Аннотация
Candida haemulonii, a relative of C. auris, frequently shows antifungal resistance and is transmissible. However, molecular tools for genotyping and investigating outbreaks are not yet established. We performed genome-based population analysis on 94 C. haemulonii strains, including 58 isolates from China and 36 other published strains. Phylogenetic analysis revealed that C. haemulonii can be divided into 4 clades. Clade 1 comprised strains from China and other global strains; clades 2-4 contained only isolates from China, were more recently evolved, and showed higher antifungal resistance. Four regional epidemic clusters (A, B, C, and D) were identified in China, each comprising ≥5 cases (largest intracluster pairwise single-nucleotide polymorphism differences <50 bp). Cluster A was identified in 2 hospitals located in the same city, suggesting potential intracity transmissions. Cluster D was resistant to 3 classes of antifungals. The emergence of more resistant phylogenetic clades and regional dissemination of antifungal-resistant C. haemulonii warrants further monitoring.