Yan ke xue bao = Eye science · 2004
[Expression of matrix metalloproteinase in human pterygia].
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Zeng Jun, Jiang Deyong, Liu Xiangping, Tang Luosheng
Аннотация
PURPOSE: To determine the cellular distribution and activation of MMP-2 and MMP-9 in human pterygium.
METHODS: The expression and activation of MMP-2 and MMP-9 were determined by immunohistochemistry and quantitative gelatinase zymography from 27 pterygia (26 cases, 18 eyes in stationary pterygia and 9 eyes in progressive pterygia) and 6 normal conjunctival specimens.
RESULTS: MMP-2 was expressed in all pterygium examined, specifically localized to the epithelium. MMP-9 was the most abundant in pterygium vascular endothelium and inflammatory cell. MMP-2 levels were no difference between the stationary pterygia [(235+/-18.17) scanning units] and the progressive pterygia [(221+/-22.53) scanning units]. MMP-9 levels in the progressive pterygia [(159+/-19.28) scanning units] were significantly higher than that in the stationary pterygia [(46+/-32.21) scanning units] (P < 0.05).
CONCLUSION: This investigation located the expression of MMP-2 and MMP-9 in pterygium of the human eyes. These enzymes may be responsible for the progression of pterygia.
METHODS: The expression and activation of MMP-2 and MMP-9 were determined by immunohistochemistry and quantitative gelatinase zymography from 27 pterygia (26 cases, 18 eyes in stationary pterygia and 9 eyes in progressive pterygia) and 6 normal conjunctival specimens.
RESULTS: MMP-2 was expressed in all pterygium examined, specifically localized to the epithelium. MMP-9 was the most abundant in pterygium vascular endothelium and inflammatory cell. MMP-2 levels were no difference between the stationary pterygia [(235+/-18.17) scanning units] and the progressive pterygia [(221+/-22.53) scanning units]. MMP-9 levels in the progressive pterygia [(159+/-19.28) scanning units] were significantly higher than that in the stationary pterygia [(46+/-32.21) scanning units] (P < 0.05).
CONCLUSION: This investigation located the expression of MMP-2 and MMP-9 in pterygium of the human eyes. These enzymes may be responsible for the progression of pterygia.