Ophthalmology · 2003
Subconjunctival mitomycin C as adjunctive therapy before pterygium excision.
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Donnenfeld Eric D, Perry Henry D, Fromer Susan, Doshi Sima, Solomon Renée, Biser Seth
Аннотация
PURPOSE: To evaluate the safety and efficacy of subconjunctival mitomycin C as adjunctive therapy before pterygium surgery.
DESIGN: Prospective noncomparative case series.
PARTICIPANTS: Thirty-six eyes of 36 patients.
INTERVENTION: Thirty-six eyes of 36 patients prospectively received 0.1 ml of 0.15 mg/ml mitomycin C subconjunctivally injected into the head of the pterygium 1 month before bare sclera surgical excision.
MAIN OUTCOME MEASURE: Recurrence of pterygia.
RESULTS: The pterygia resolved in 34 (94%) of 36 eyes, with a recurrence rate of 6% over a mean follow-up of 24.4 months. No wound-healing complication developed in any patient.
CONCLUSIONS: Subconjunctival mitomycin C is an effective treatment before pterygium excision. Subconjunctival injection allows exact titration of mitomycin C delivery to the activated fibroblasts and minimizes epithelial toxicity.
DESIGN: Prospective noncomparative case series.
PARTICIPANTS: Thirty-six eyes of 36 patients.
INTERVENTION: Thirty-six eyes of 36 patients prospectively received 0.1 ml of 0.15 mg/ml mitomycin C subconjunctivally injected into the head of the pterygium 1 month before bare sclera surgical excision.
MAIN OUTCOME MEASURE: Recurrence of pterygia.
RESULTS: The pterygia resolved in 34 (94%) of 36 eyes, with a recurrence rate of 6% over a mean follow-up of 24.4 months. No wound-healing complication developed in any patient.
CONCLUSIONS: Subconjunctival mitomycin C is an effective treatment before pterygium excision. Subconjunctival injection allows exact titration of mitomycin C delivery to the activated fibroblasts and minimizes epithelial toxicity.