[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · 1999
[Cytokine assays for pterygium].
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Zhang J, Jin W, Lin Y, Zhang G
Аннотация
OBJECTIVE: To study the roles of tumor necrosis factor (TNF-alpha) and platelet-derived growth factor (PDGF) in pathogenesis of pterygium.
METHODS: Radioimmunoassay and bioactivity assay were used to measure the levels of TNF-alpha and PDGF in tissue culture supernatant of pterygium specimens obtained from 30 patients.
RESULTS: The levels of TNF-alpha and PDGF in tissue culture supernatant of pterygium were significantly higher than that of normal conjunctival specimens (t = 2.827, P < 0.01; t = 3.011, P < 0.01), and there was a significant difference between progressive and quiescent cases (t = 2.374, P < 0.05; t = 2.712, P < 0.05).
CONCLUSIONS: The abnormal secretion of TNF-alpha and PDGF may be related to the pathogenesis of pterygium.
METHODS: Radioimmunoassay and bioactivity assay were used to measure the levels of TNF-alpha and PDGF in tissue culture supernatant of pterygium specimens obtained from 30 patients.
RESULTS: The levels of TNF-alpha and PDGF in tissue culture supernatant of pterygium were significantly higher than that of normal conjunctival specimens (t = 2.827, P < 0.01; t = 3.011, P < 0.01), and there was a significant difference between progressive and quiescent cases (t = 2.374, P < 0.05; t = 2.712, P < 0.05).
CONCLUSIONS: The abnormal secretion of TNF-alpha and PDGF may be related to the pathogenesis of pterygium.