Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk.
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Valle-Hita Cristina, Díaz-López Andrés, Becerra-Tomás Nerea, Martínez-González Miguel A, García Verónica Ruiz, Corella Dolores, Goday Albert, Martínez J Alfredo, Alonso-Gómez Ángel M, Wärnberg Julia, Vioque Jesús, Romaguera Dora, López-Miranda José, Estruch Ramon, Tinahones Francisco J, Lapetra José, Serra-Majem Luís, Cano-Ibáñez Naomi, Tur Josep A, Rubín-García María, Pintó Xavier, Delgado-Rodríguez Miguel, Matía-Martín Pilar, Vidal Josep, Fontao Sebastian Mas, Daimiel Lidia, Ros Emilio, Toledo Estefania, Sorlí José V, Roca C, Abete Iztiar, Moreno-Rodriguez Anai, Crespo-Oliva Edelys, Candela-García Inmaculada, Morey Marga, Garcia-Rios Antonio, Casas Rosa, Fernandez-Garcia Jose Carlos, Santos-Lozano José Manuel, Diez-Espino Javier, Ortega-Azorín Carolina, Comas M, Zulet M Angeles, Sorto-Sanchez Carolina, Ruiz-Canela Miguel, Fitó Montse, Salas-Salvadó Jordi, Babio Nancy
Аннотация
METHODS: We prospectively analyzed 5675 participants (55-75 years) from the PREDIMED-Plus study. At baseline and at one year, we evaluated the creatinine-based estimated glomerular filtration rate (eGFR) and food-frequency questionnaires-derived dietary scores. Associations between four categories (decrease/maintenance and tertiles of increase) of each dietary pattern and changes in eGFR (ml/min/1.73m2) or ≥ 10% eGFR decline were assessed by fitting multivariable linear or logistic regression models, as appropriate.
RESULTS: Participants in the highest tertile of increase in 17-item erMedDiet Score showed higher upward changes in eGFR (β: 1.87 ml/min/1.73m2; 95% CI: 1.00-2.73) and had lower odds of ≥ 10% eGFR decline (OR: 0.62; 95% CI: 0.47-0.82) compared to individuals in the decrease/maintenance category, while Trichopoulou-MedDiet and DASH Scores were not associated with any renal outcomes. Those in the highest tertile of increase in Protein Diet Score had greater downward changes in eGFR (β: - 0.87 ml/min/1.73m2; 95% CI: - 1.73 to - 0.01) and 32% higher odds of eGFR decline (OR: 1.32; 95% CI: 1.00-1.75).
CONCLUSIONS: Among elderly individuals with overweight/obesity and MetS, only higher upward change in the 17-item erMedDiet score adherence was associated with better kidney function after one year. However, increasing Protein Diet Score appeared to have an adverse impact on kidney health.
TRIAL REGISTRATION NUMBER: ISRCTN89898870 (Data of registration: 2014).