Scientific reports · 2021
Association between pulse pressure and progression of chronic kidney disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Maeda Toshiki, Yokota Soichiro, Nishi Takumi, Funakoshi Shunsuke, Tsuji Masayoshi, Satoh Atsushi, Abe Makiko, Kawazoe Miki, Yoshimura Chikara, Tada Kazuhiro, Takahashi Koji, Ito Kenji, Yasuno Tetsuhiko, Yamanokuchi Toshitaka, Iwanaga Kazuyo, Morinaga Akiko, Maki Kaori, Ueno Tamami, Masutani Kousuke, Mukoubara Shigeaki, Arima Hisatomi
Аннотация
The aim of this study was to investigate the association between pulse pressure (PP) and chronic kidney disease (CKD) progression among the general population in Japan. We conducted a population-based cohort study of the residents of Iki Island, Nagasaki, Japan, from 2008 to 2018. We identified 1042 participants who had CKD (estimated glomerular filtration rate(eGFR) < 60 mL/min/1.73 m2 or the presence of proteinuria) at baseline. Cox's proportional hazard model was used to evaluate the association between PP and progression of CKD. During a 4.66-year mean follow-up, there were 241 cases of CKD progression (incident rate: 49.8 per 1000 person-years). A significant increase existed in CKD progression per 10 mmHg of PP elevation, even when adjusted for confounding factors [adjusted hazard ratio 1.17 (1.06-1.29) p < 0.001]. Similar results were obtained even after dividing PP into quartiles [Q2: 1.14 (0.74-1.76), Q3: 1.35 (0.88-2.06), Q4: 1.87 (1.23-2.83) p = 0.003 for trend]. This trend did not change significantly irrespective of baseline systolic or diastolic blood pressures. PP remained a potential predictive marker, especially for eGFR decline. In conclusion, we found a significant association between PP and CKD progression. PP might be a potential predictive marker for CKD progression.