Immunity · 2022
Antigenic cartography using sera from sequence-confirmed SARS-CoV-2 variants of concern infections reveals antigenic divergence of Omicron.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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van der Straten Karlijn, Guerra Denise, van Gils Marit J, Bontjer Ilja, Caniels Tom G, van Willigen Hugo D G, Wynberg Elke, Poniman Meliawati, Burger Judith A, Bouhuijs Joey H, van Rijswijk Jacqueline, Olijhoek Wouter, Liesdek Marinus H, Lavell A H Ayesha, Appelman Brent, Sikkens Jonne J, Bomers Marije K, Han Alvin X, Nichols Brooke E, Prins Maria, Vennema Harry, Reusken Chantal, de Jong Menno D, de Bree Godelieve J, Russell Colin A, Eggink Dirk, Sanders Rogier W
Аннотация
Large-scale vaccination campaigns have prevented countless hospitalizations and deaths due to COVID-19. However, the emergence of SARS-CoV-2 variants that escape from immunity challenges the effectiveness of current vaccines. Given this continuing evolution, an important question is when and how to update SARS-CoV-2 vaccines to antigenically match circulating variants, similarly to seasonal influenza viruses where antigenic drift necessitates periodic vaccine updates. Here, we studied SARS-CoV-2 antigenic drift by assessing neutralizing activity against variants of concern (VOCs) in a set of sera from patients infected with viral sequence-confirmed VOCs. Infections with D614G or Alpha strains induced the broadest immunity, whereas individuals infected with other VOCs had more strain-specific responses. Omicron BA.1 and BA.2 were substantially resistant to neutralization by sera elicited by all other variants. Antigenic cartography revealed that Omicron BA.1 and BA.2 were antigenically most distinct from D614G, associated with immune escape, and possibly will require vaccine updates to ensure vaccine effectiveness.