Science translational medicine · 2022
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery.
СтатьяПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Frere Justin J, Serafini Randal A, Pryce Kerri D, Zazhytska Marianna, Oishi Kohei, Golynker Ilona, Panis Maryline, Zimering Jeffrey, Horiuchi Shu, Hoagland Daisy A, Møller Rasmus, Ruiz Anne, Kodra Albana, Overdevest Jonathan B, Canoll Peter D, Borczuk Alain C, Chandar Vasuretha, Bram Yaron, Schwartz Robert, Lomvardas Stavros, Zachariou Venetia, tenOever Benjamin R
Аннотация
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we compared the short- and long-term systemic responses in the golden hamster after either SARS-CoV-2 or influenza A virus (IAV) infection. Results demonstrated that SARS-CoV-2 exceeded IAV in its capacity to cause permanent injury to the lung and kidney and uniquely affected the olfactory bulb (OB) and olfactory epithelium (OE). Despite a lack of detectable infectious virus, the OB and OE demonstrated myeloid and T cell activation, proinflammatory cytokine production, and an interferon response that correlated with behavioral changes extending a month after viral clearance. These sustained transcriptional changes could also be corroborated from tissue isolated from individuals who recovered from COVID-19. These data highlight a molecular mechanism for persistent COVID-19 symptomology and provide a small animal model to explore future therapeutics.