Metabolomics : Official journal of the Metabolomic Society · 2025
Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection.
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Lee Tzu-Hao, Wegermann Kara, Safeek Rachel, Mock Meredith, Lusk Sam, John-Williams Lisa St, Thompson Will J, Lucas Joseph E, Moseley M Arthur, Patel Keyur, Naggie Susanna
Аннотация
Non-invasive assessments for advanced liver fibrosis have limited accuracy in persons with human immunodeficiency virus (HIV) (PWH) who have hepatitis C virus (HCV) co-infection, and new tools are needed. Our aim was to discover oxylipin profiles associated with advanced liver fibrosis in treatment-naïve patients with HIV/HCV co-infection. Serum samples from 40 PWH with HCV were subjected to targeted oxylipin analysis. A model with AST and seven metabolites, including 5(S)-HEPE, 8-HETE, 14,15-DiHETrE, 4-HDoHE, 14- HDoHE, 7-HDoHE, and 9,10-DiHOME yielded an area under the receiver operating characteristic curve of 0.93, with optimal sensitivity and specificity of 86% and 88%, respectively.