Health science reports · 2026
Improvement in the Microbiological Diagnosis of Hepatitis D on the Mediterranean Coast of Southeastern Spain: A Repeated Cross-Sectional Survey.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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История · было → стало
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Ventero Maria Paz, Tyshkovska Iryna, Castillo-Sanchez Jose Carlos, Reus Sergio, de la Rica Alba, Orta Nieves, Serrat Conxa, Gil Maria, Ortiz de la Tabla Victoria, Navarro David, Belda Sofia, Martinez Olalla, Coy Javier, Simón Victoria, Magraner Josefina, Gimeno Concepcion, Shalabi Maruan, Garcia-Aguayo Jose María, Tirado-Balaguer M Dolores, Dominguez Victoria, Ruiz M Montserrat, Gascón Isabel, Roig Mercedes, Giner Salvador, González Rosa, Fuentes Encarna, Llopis Coral, Rodriguez Juan Carlos
Аннотация
BACKGROUND: Hepatitis D virus (HDV) remains underdiagnosed, and universal screening of HBsAg-positive patients is recommended. We assessed changes in HDV diagnostic capacity across public hospitals in the Valencian Community, Spain.
METHODS: Repeated cross-sectional surveys were conducted in 2024 and 2025. Analyses included the 19 hospitals participating in both years and evaluated anti-HDV testing, HDV RNA detection, reflex testing, and clinician notification.
RESULTS: Anti-HDV testing increased from 84.2% to 94.7%, HDV RNA testing from 68.4% to 84.2%, reflex testing from 43.8% to 77.8% (p = 0.04), and direct clinician communication from 75.0% to 83.3%. Improvements were most marked in hospitals with fewer than 500 beds, where anti-HDV testing rose from 78.6% to 92.9% and HDV RNA testing from 57.1% to 78.6%.
CONCLUSIONS: HDV diagnostic capacity improved substantially, particularly in smaller hospitals. Further organizational measures are needed to achieve universal double-reflex testing and timely communication of positive results.
METHODS: Repeated cross-sectional surveys were conducted in 2024 and 2025. Analyses included the 19 hospitals participating in both years and evaluated anti-HDV testing, HDV RNA detection, reflex testing, and clinician notification.
RESULTS: Anti-HDV testing increased from 84.2% to 94.7%, HDV RNA testing from 68.4% to 84.2%, reflex testing from 43.8% to 77.8% (p = 0.04), and direct clinician communication from 75.0% to 83.3%. Improvements were most marked in hospitals with fewer than 500 beds, where anti-HDV testing rose from 78.6% to 92.9% and HDV RNA testing from 57.1% to 78.6%.
CONCLUSIONS: HDV diagnostic capacity improved substantially, particularly in smaller hospitals. Further organizational measures are needed to achieve universal double-reflex testing and timely communication of positive results.