Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2017
[Effects of voice therapy and psychological intervention on anxious and depressive in patients with voice disorders].
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Zheng J, Wei X, Zhan J B, Jiang H Y
Аннотация
Objective:To investigate the expression of miR 34a in epithelial cells of nasal polyps (NPs) and to determine its effects on hypoxia induced epithelial mesenchymal transition (EMT).method:Nasal epithelial cells (NECs) were collected from NPs and normal inferior turbinates. miR-34a expression was detected by means of quantitative reverse transcriptase polymerase chain reaction. In addition, normal NECs were cultured under normoxia/hypoxia conditons. The effects of miR-34a mimics on hypoxia induced EMT were investigated.result:miR-34a was specifically down-regulated in NECs of NP. Hypoxia decreased miR-34a expression in vitro. Furthermore, E-cadherin and α-SMA were down-regulated and up-regulated, respectively. miR-34a mimics transfection can reverse this process.Conclusion:miR-34a suppress hypoxia-induced EMT in NECs. The down-regulation of miR-34a may contribute to nasal polypogenesis.