Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Defazio Giovanni, Fabbrini Giovanni, Erro Roberto, Albanese Alberto, Barone Paolo, Zibetti Maurizio, Esposito Marcello, Pellicciari Roberta, Avanzino Laura, Bono Francesco, Eleopra Roberto, Bertolasi Laura, Altavista Maria Concetta, Cotelli Maria Sofia, Ceravolo Roberto, Scaglione Cesa, Bentivoglio Anna Rita, Cossu Giovanni, Coletti Moja Mario, Girlanda Paolo, Misceo Salvatore, Pisani Antonio, Mascia Marcello Mario, Ercoli Tommaso, Tinazzi Michele, Maderna Luca, Minafra Brigida, Magistrelli Luca, Romano Marcello, Aguggia Marco, Tambasco Nicola, Castagna Anna, Cassano Daniela, Berardelli Alfredo, Italian Dystonia Registry Participants
Аннотация
MATERIALS AND METHODS: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia.
RESULTS: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development.
DISCUSSION AND CONCLUSION: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.