NeuroRehabilitation · 2019
Is deep brain stimulation (DBS) a safe and effective treatment for adults with dystonia? - A Cochrane Review summary with commentary.
СтатьяСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Cecchi Francesca
Аннотация
BACKGROUND: Dystonia is the third common motor disorder; deep brain stimulation (DBS) has been reported as beneficial in selected dystonia patients.
OBJECTIVE: To assess the effects of DBS in adults with dystonia.
METHODS: Cochrane Review conducted by Rodrigues et al. searching for RCTs with a parallel design, comparing DBS versus placebo, sham intervention, or best medical/surgical treatment was summarized and discussed from a rehabilitation perspective.
RESULTS: Only two RCTs, at high risk of bias, and comparing DBS with sham intervention, were selected; low quality evidence was found that DBS may improve specific symptoms and functionality in adults with cervical or segmental/generalized dystonia; no conclusion was reached on DBS safety and tolerability.
CONCLUSIONS: High quality studies are needed to verify DBS effects in dystonia; more types of dystonia and other control interventions also need to be addressed.
OBJECTIVE: To assess the effects of DBS in adults with dystonia.
METHODS: Cochrane Review conducted by Rodrigues et al. searching for RCTs with a parallel design, comparing DBS versus placebo, sham intervention, or best medical/surgical treatment was summarized and discussed from a rehabilitation perspective.
RESULTS: Only two RCTs, at high risk of bias, and comparing DBS with sham intervention, were selected; low quality evidence was found that DBS may improve specific symptoms and functionality in adults with cervical or segmental/generalized dystonia; no conclusion was reached on DBS safety and tolerability.
CONCLUSIONS: High quality studies are needed to verify DBS effects in dystonia; more types of dystonia and other control interventions also need to be addressed.