Oceans Apart - at the extremes of personalised care in the new Cystic Fibrosis paradigm.

The advent of CFTR modulators has revolutionised Cystic Fibrosis (CF) care, improving life expectancy, physiological parameters and reducing exacerbations. These are matched by changes in life expectations and ambitions of people living with CF (pwCF). This case study follows Sophie, a pwCF who completed a 54-day transatlantic row in early 2025, posing a unique challenge to our multidisciplinary team (MDT) that required bespoke support before, during and after her historic achievement.