[Prognostic impact of new treatmentsfor cystic fibrosis].

PROGNOSTIC IMPACT OF NEW TREATMENTS FOR CYSTIC FIBROSIS. The prognosis of cystic fibrosis has improved over the past 25 years, due to the introduction of widespread neonatal screening, a structured organization of care and advances in symptomatic treatments. The large use of CFTR protein modulators represents a new stage in the improvement of prognosis and median survival estimates. This is reflected in a steady increase in the adult patient population, an ageing population associated with the onset of metabolic and cardiovascular complications, and more frequent cancers, particularly gastrointestinal. As a result, current symptomatic treatments are being reduced and follow-up recommendations adapted to these new challenges. However, the treatment effect is merely suspensive, and its long-term efficacy and safety have yet to be assessed.